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Functional Characterization of Novel Beta-Lactamase and Aminoglycoside-Resistance Variants

Agricultural Microbiology

AMR in Agricultural Soil Environments Research

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Agricultural Microbiology › AMR in Agricultural Soil Environments Research

Functional Characterization of Novel Beta-Lactamase and Aminoglycoside-Resistance Variants

This research biochemically and genetically characterizes previously unknown or undercharacterized resistance enzyme variants isolated from agricultural soil bacteria to determine their kinetic properties and substrate specificities. The structural and mechanistic insights advance understanding of resistance evolution and inform the design of novel antimicrobial agents that circumvent emerging resistance mechanisms.

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