Cancer Systems Biology › Cancer Genomics Mutation Burden Analysis
Tumor Mutational Burden (TMB) Quantification and Stratification
Interns will learn to calculate and analyze tumor mutational burden from whole-exome or whole-genome sequencing data across different cancer types. They will develop skills in quantifying mutation counts, normalizing by coding sequence length, and stratifying patients into TMB-high and TMB-low categories for immunotherapy prediction and prognosis assessment.
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