Cancer-Associated Epigenetic Mutations and Chromatin Dysfunction

Molecular Cancer Research › Chromatin Remodeling Cancer Epigenetics

Cancer-Associated Epigenetic Mutations and Chromatin Dysfunction

Interns will study recurrent mutations in chromatin remodeling genes (ARID1A, PBRM1, BAP1) and histone modifiers found in various cancer types using bioinformatics and functional validation approaches. This includes analyzing mutation databases, performing structural modeling, and conducting functional assays to determine how these mutations compromise chromatin homeostasis and promote tumorigenesis.

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