Mutational Signature Extraction and De Novo Discovery

Clinical Medical Bioinformatics › Cancer Genomics Mutation Signature Analysis

Mutational Signature Extraction and De Novo Discovery

Interns will apply non-negative matrix factorization (NMF) and machine learning algorithms to extract mutational signatures from cancer genomic datasets. They will work with tools like SigProfiler and Palimpsest to identify both known signatures and discover novel signatures associated with specific etiological factors such as UV exposure, smoking, or APOBEC activity. This includes validation of extracted signatures against COSMIC and other reference databases.

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